Assessment of residual tumour by FDG-PET: conventional imaging and clinical examination following primary chemotherapy of large and locally advanced b

Assessment of residual tumour by FDG-PET: conventional imaging and clinical examination following primary chemotherapy of large and locally advanced breast cancer
J Dose-Schwarz, R Tiling, S Avril-Sassen, S Mahner, A Lebeau, C Weber, M Schwaiger, F Jänicke, M Untch and N Avril
Br J Cancer 2010 102: 35-41

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FDG-PET does not provide an accurate assessment of residual tumour after primary chemotherapy of breast cancer. Magnetic resonance imaging offers the highest sensitivity, but all imaging modalities have distinct limitations in the assessment of residual tumour tissue when compared with histopathology

Radiological and pathological size estimations of pure ductal carcinoma in situ of the breast

Radiological and pathological size estimations of pure ductal carcinoma in situ of the breast, specimen handling and the influence on the success of breast conservation surgery: a review of 2564 cases from the Sloane Project
J Thomas, A Evans, J Macartney, S E Pinder, A Hanby, I Ellis, O Kearins, T Roberts, K Clements, G Lawrence and H Bishop on behalf of the Sloane Project Steering Group
Br J Cancer 2010 102: 285-293

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In a large series of screen-detected DCIS, we have shown that current approaches to preoperative imaging undersize the extent of disease in patients selected for BCS in up to 30% of cases, with the consequence of failed primary conservation surgery.
Further improvements in preoperative assessment should include detailed discussion between surgeon, radiologist and pathologist about radiological – pathological size correlation, particularly the extent of colocation of microcalcification and DCIS. Our data suggest that such discussion should be particularly targeted at intermediate and low-grade disease